The diversion for drivers wishing to continue west will be to head north on the M1 and along the M621.
Highways England are closing the M62 for an entire weekend in one direction for road improvement works.
Teams will be carrying out essential repair work on the westbound M62 between junctions 29 and 28 from 8pm on Friday 14 June to 5am on Monday 17 June.
Ardsley Railway Bridge, which sits between junctions 29 and 28 of the westbound M62, needs to be re-waterproofed to maintain the bridge and prevent it from deteriorating. Highways England say waterproofing a bridge protects the concrete from slowly being damaged by rainwater and road salt.
Highways England project manager Dan Edwards said: “Safety is our top priority and with that in mind, it’s crucial that we carry out this repair work now to stop the bridge deteriorating to a point that it could become a safety issue.
“We have worked closely with Leeds City Council to choose a weekend that doesn’t conflict with any major events, and we have selected a time of year when we see less traffic. Picking a weekend in June also gives us the best chance of getting the dry weather we need to carry out the waterproofing.
“We understand a full closure of the westbound M62 will cause disruption, so we are letting people know five weeks in advance in order that drivers can start planning their journeys. We will be putting up signs on all the motorways across the area and have been in discussions with local organisations about our plans.”
The diversion for drivers wishing to continue west will be to head north on the M1 and along the M621 before re-joining the M62 at junction 27. Drivers wanting to go only as far as junction 28 on the M62 can leave the M621 at junction 1.