It happened last night in the Wyke area on Huddersfield Road.
West Yorkshire Police are investigating a serious road traffic collision in Bradford.
It happened at about 8.16pm yesterday, when a Ford Focus hit a Volkswagen Polo travelling in the opposite direction.
The incident occurred in the Wyke area on Huddersfield Road.
A 22-year-old woman from Bradford, suffered serious injuries and remains in hospital today where she is in a stable condition.
An 18-year-old woman, also from Bradford, was also taken to hospital to be treated for minor injuries.
West Yorkshire Police area appealing for anyone who witnessed the collision to contact the Western Area Roads Policing Unit on 101, quoting log 1815 of 15 May.